| Date | Time | Visitor | Home | Venue | Download | Visitor Score | Home Score | Winner |
|---|---|---|---|---|---|---|---|---|
| 2021/09/16 | 3:00 | Marion Graham | Centennial | SMF | Video | 24 | 38 | Centennial |
| 5:15 | North Battleford | Aden Bowman | SMF | Video | 14 | 7 | North Battleford | |
| 7:30 | Holy Cross | St Joseph | SMF | Video | 5 | 13 | St Joseph | |
| 2021/09/17 | 12:45 | Mount Royal | ED Feehan | SMF | Video | 8 | 48 | ED Feehan |
| 15:00 | Carlton | Tommy Douglas | SMF | Video | 37 | 0 | Carlton | |
| 17:15 | Bethlehem | Walter Murray | SMF | Video | 11 | 4 | Bethlehem | |
| 18:30 | Bedford Road | PA St Mary | Prince Albert | Video | 0 | 21 | PA St Mary | |
| 19:30 | Evan Hardy | Bishop J. Mahoney | SMF | Video | 7 | 23 | Bishop J. Mahoney | |
| 2021/09/23 | 3:00 | Bedford Road | Mount Royal | SMF | Video | 35 | 6 | Bedford Road |
| 5:15 | ED Feehan | Evan Hardy | SMF | Video | 0 | 38 | Evan Hardy | |
| 6:31 | Marion Graham | North Battleford | North Battleford | Video | 25 | 28 | North Battleford | |
| 7:30 | Aden Bowman | Bishop J. Mahoney | SMF | Video | 7 | 8 | Bishop J. Mahoney | |
| 2021/09/24 | 3:00 | Holy Cross | Centennial | SMF | Video | 43 | 0 | Holy Cross |
| 5:15 | St Joseph | Tommy Douglas | SMF | Video | 40 | 0 | St Joseph | |
| 6:30 | Bethlehem | Carlton | Prince Albert | Video | 24 | 34 | Carlton | |
| 7:30 | PA St Mary | Walter Murray | SMF | Video | 4 | 6 | Walter Murray | |
| 2021/09/30 | 3:00 | PA St Mary | Bethlehem | SMF | Video | 41 | 14 | PA St Mary |
| 5:15 | Tommy Douglas | Bedford Road | SMF | Video | 39 | 8 | Tommy Douglas | |
| 6:30 | Walter Murray | Carlton | Prince Albert | Video | 45 | 27 | Walter Murray | |
| 7:30 | Marion Graham | Evan Hardy | SMF | Video | 21 | 0 | Marion Graham | |
| 2021/10/01 | 3:00 | Aden Bowman | Holy Cross | SMF | Video | 17 | 50 | Holy Cross |
| 5:15 | ED Feehan | Mount Royal | SMF | Video | 49 | 0 | ED Feehan | |
| 6:30 | Bishop J. Mahoney | North Battleford | North Battleford | Video | 24 | 0 | Bishop J. Mahoney | |
| 7:30 | Centennial | St Joseph | SMF | Video | 7 | 52 | St Joseph | |
| 2021/10/07 | 5:15 | Bedford Road | ED Feehan | SMF | Video | 28 | 14 | Bedford Road |
| 6:30 | Evan Hardy | North Battleford | North Battleford | Video | 9 | 20 | North Battleford | |
| 7:30 | Centennial | Holy Cross | SMF | Video | 0 | 37 | Holy Cross | |
| 2021/10/08 | 3:00 | Bishop J. Mahoney | St Joseph | SMF | Video | 14 | 52 | St Joseph |
| 5:15 | Aden Bowman | Marion Graham | SMF | Video | 15 | 6 | Aden Bowman | |
| 7:30 | Tommy Douglas | Walter Murray | SMF | Video | 6 | 41 | Walter Murray | |
| 2021/10/14 | 3:00 | Bethlehem | Tommy Douglas | SMF | Video | 35 | 0 | Bethlehem |
| 5:15 | Walter Murray | Centennial | SMF | Video | 44 | 0 | Walter Murray | |
| 7:30 | Bishop J. Mahoney | Marion Graham | SMF | Video | 41 | 6 | Bishop J. Mahoney | |
| 2021/10/15 | 3:00 | Mount Royal | Bedford Road | SMF | Video | 0 | 41 | Bedford Road |
| 5:15 | Evan Hardy | Aden Bowman | SMF | Video | 0 | 19 | Aden Bowman | |
| 6:30 | North Battleford | PA St Mary | Prince Albert | Video | 12 | 35 | PA St Mary | |
| 7:30 | St Joseph | Holy Cross | SMF | Video | 24 | 31 | Holy Cross | |
| 2021/10/21 | 5:15 | Holy Cross | Bethlehem | SMF | Video | 49 | 14 | Holy Cross |
| 6:30 | Tommy Douglas | PA St Mary | Prince Albert | Video | 12 | 42 | PA St Mary | |
| 7:30 | St Joseph | Centennial | SMF | Video | 52 | 0 | St Joseph | |
| 2021/10/22 | 3:00 | ED Feehan | Bedford Road | SMF | Video | 20 | 14 | ED Feehan |
| 5:15 | Marion Graham | Bishop J. Mahoney | SMF | Video | 7 | 35 | Bishop J. Mahoney | |
| 6:30 | Evan Hardy | Carlton | Prince Albert | Video | 0 | 28 | Carlton | |
| 7:30 | Aden Bowman | North Battleford | SMF | Video | 25 | 7 | Aden Bowman | |
| 2021/10/27 | 3:00 | Mount Royal | ED Feehan | SMF | Video | 12 | 48 | ED Feehan |
| 5:15 | Evan Hardy | PA St Mary | SMF | Video | 0 | 39 | PA St Mary | |
| 7:30 | Bethlehem | Carlton | SMF | Video | 12 | 28 | Carlton | |
| 2021/10/28 | 5:15 | Walter Murray | St Joseph | SMF | Video | 14 | 28 | St Joseph |
| 7:30 | Centennial | Holy Cross | SMF | Video | 7 | 41 | Holy Cross | |
| 2021/10/29 | 5:00 | Bedford Road | Tommy Douglas | SMF | Video | 0 | 42 | Tommy Douglas |
| 7:30 | Aden Bowman | Bishop J. Mahoney | SMF | Video | 3 | 17 | Bishop J. Mahoney | |
| 2021-11-04 | 6:30 | Carlton | PA St Mary | Prince Albert | Video | 14 | 35 | PA St Mary |
| 2021-11-05 | 6:30 | St Joseph | Holy Cross | SMF | Video | 0 | 26 | Holy Cross |
| 2021/11/06 | 1:00 | Bishop J. Mahoney | Weyburn | Weyburn Comprehensive | No Video | 13 | 24 | Weyburn |
| 2021-11-12 | 6:30 | Weyburn | Balgonie Greenall | Regina | No Video | 44 | 0 | Weyburn |
| 2021-11-13 | 1:00 | Regina Miller | Holy Cross | SMF | Video | 28 | 24 | Regina Miller |